The Un-Equal Family: Unraveling the Evolution of Mycobacteria's PE_PGRS Proteins 🧬🦠| #sciencefather #researchaward
 
 Hello, researchers and technicians! 👋 When we talk about Mycobacteria , our minds often go straight to Mycobacterium tuberculosis , the formidable pathogen behind tuberculosis, a disease that remains a major global health threat. Part of what makes this bacterium so resilient is its complex and sophisticated genetic makeup, which includes a particularly curious family of proteins known as PE_PGRS . For years, these proteins, characterized by their repetitive structure, were something of a genetic enigma. They are one of the largest gene families in mycobacteria, yet their function has remained a subject of intense debate. A recent study, however, dives into their evolutionary history, asking a profound question: are all PE_PGRS proteins created equal, or have some evolved to become more important than others? 🤔 A Family of Repetition and Diversity 🤷♂️ The name itself gives us clues to their structure: PE Domain:  A conserved, stable region at one end of the protein. PGRS Domai...
 
 
 
 
 
 
 
 
 
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